251 - The Future of Drug Delivery: Orals, Injectables, Sustainability & Device Strategy

Let's Combinate · 24 Aug 2026 · 49m

What this episode covers

Steven Kaufman, Founder of Combination Product Solutions and fractional CCO at Portal Instruments, discusses the evolving drug delivery landscape, highlighting the shift toward larger-volume subcutaneous injections (5-10 mL) and the critical role of sustainability in device selection. He explains that while oral GLP-1s are popular, injectables offer superior efficacy and adherence for many patients, driving demand for both disposable and reusable auto-injectors. Kaufman emphasizes that commercial success in 2026 requires solving specific challenges like high viscosity and injection time, rather than just competing on price or form factor. He predicts that sustainability will be the dominant force shaping the next generation of devices through 2035, with companies like Eco-Injet and Portal leading the way.

Mentioned

Companies
Portal Instruments, SHL Medical, Ipsen, Novo Nordisk, Sanofi, Owen Mumford, West, Gershheimer, BD, LTS, Enable, Schott, Becton Dickinson, Devenado, Halozyme, Koru, Cormica, Kaimonox, Guestnet, One World, Noble
Products
Eco-Injet, Mali

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