Hardware Podcasts

254 - Saying No Is the Easy Part of Quality

Let's Combinate · 13 Sept 2026 · 12m

What this episode covers

Subhi Saadeh, founder of Let’s Combinate, outlines four scenarios where quality professionals must firmly say no, including real patient risk, insufficient evidence, requirement violations, and schedule pressure. He contrasts these with three weak reasons for saying no, such as personal preference, technical uncertainty, and applying excessive GMP rigor to early-stage development. Saadeh advocates for a flexible quality culture that distinguishes between rigid compliance and risk-based decision-making, using a drug delivery platform case study to illustrate evidence-based stops.

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early-stage companies

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The Effective Executive

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