# 146 - Lyophilization/Freeze-Drying, Filling, Sublimation, Disorption, Backfilling, Stoppers, Vacuum and Water's Triple Point with David Simoens

- Show: [Let's Combinate](https://hardwarepodcasts.com/podcast/lets-combinate)
- Published: 2024-07-24
- Length: 35m
- Page: https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop
- Listen: https://podcasters.spotify.com/pod/show/letscombinate/episodes/146---LyophilizationFreeze-Drying--Filling--Sublimation--Disorption--Backfilling--Stoppers--Vacuum-and-Waters-Triple-Point-with-David-Simoens-e2mcb59

## Summary

David Simoens, founder of Life Science Professionals, explains the lyophilization (freeze-drying) process for pharmaceutical products, detailing the transition from liquid to solid state via sublimation and desorption. He distinguishes between liquid-filled and lyo-filled vials, highlighting the specific use of specialized stoppers (like igloo or multi-legged designs) that allow solvent escape during drying. The discussion covers the technical parameters of the freeze-dryer cycle, including freezing, primary drying at the triple point of water, secondary drying, and backfilling with nitrogen to ensure product stability.

## Chapters

- [0:00](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=0) Introduction: David Simoens and Life Science Professionals
- [3:04](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=184) Lyophilization Definition and Stabilization Goals
- [4:22](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=262) Vial Filling and Stopper Differences: Lyo vs. Liquid
- [9:44](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=584) Freeze Drying Process and Shelf Loading Requirements
- [15:30](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=930) Primary and Secondary Drying: Sublimation and Desorption
- [15:30](https://hardwarepodcasts.com/podcast/lets-combinate/2024-07-24-146-lyophilization-freeze-drying-filling-sublimation-disorption-backfilling-stop#t=930) Backfilling, Stoppering, and Equipment Considerations

## Topics

- [Materials & manufacturing processes](https://hardwarepodcasts.com/topic/materials-and-processes)
- [Mechanical engineering](https://hardwarepodcasts.com/topic/mechanical-engineering)
- [Quality & yield](https://hardwarepodcasts.com/topic/quality-and-yield)

## Most relevant to

early-stage companies

## Mentioned

- Life Science Professionals (company)
- ASTM E2500 (other)
- ISPE Baseline Volume 5 (other)

## Citing this page

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